Bank of America Background Bank of America, with total assets of $2.2 trillion, is the second largest bank holding company in the U.S. by assets. It’s one of the ‘Big Four’ banks in the U.S., and was listed by Forbes in 2010 as the third-largest company in the U.S. Bank of America operates – but doesn’t have banking centers – in all 50 states, the District of Columbia and 40 other countries. Bank of America